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Caterina Ramogida, Associate Professor of Chemistry, Simon Fraser University

https://www.sfu.ca/chemistry/department/faculty-staff/profiles/research-...

Group website: https://ramogidagroup.weebly.com/

Research: Nuclear Medicinal Inorganic Chemistry

Nuclear medicine is a powerful technique with the ability to both image disease non-invasively and subsequently treat the diseased state by injecting a radioactive isotope fused to a designer molecule that can transport the radionuclide specifically to the diseased tissue. Our research focuses on the development of novel pharmaceuticals which incorporate radioactive metal ions (aka radiometals) for both molecular imaging and targeted therapy of disease. We design, synthesize, characterize, and evaluate (in vitro and in vivo) metal-based radiopharmaceuticals, with an emphasis on understanding the coordination chemistry used to tether the radiometal ion to the biomolecular targeting vector (Figure 1). This interdisciplinary research bridges the fields of chemistry, biology, and radiology. We work closely with our collaborators at TRIUMF – Canada’s particle accelerator centre (www.triumf.ca) – to produce innovative and unconventional radiometals, and BC Cancer – to evaluate our radiopharmaceuticals in vivo.